Description

Cm-Trisacryl M is a specialized, high-performance chromatography medium designed for industrial-scale biomolecule purification. This product matters for its robust mechanical strength and consistent performance, which are critical for ensuring high yield and purity in downstream bioprocessing. It is primarily needed by manufacturers in the biotechnology and pharmaceutical industries for the purification of proteins, monoclonal antibodies, and other sensitive biological molecules.

Application

• Industrial-scale purification of monoclonal antibodies (mAbs) and antibody fragments.
• Downstream processing of recombinant proteins and enzymes.
• Capture and intermediate purification steps in biopharmaceutical manufacturing.
• Polishing step to remove aggregates and impurities from biological solutions.
• Process development and scale-up in research and production laboratories.
• Purification of vaccines and other therapeutic biological products.

Basic Information

Product Name	Cm-Trisacryl M
CAS No.	79748-37-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Trisacryl M CM; CM-Trisacryl; Carboxymethyl Trisacryl M; CM-Trisacryl Matrix; Trisacryl CM; Weak Cation Exchanger Trisacryl; CM Functionalized Acrylic Polymer; Poly(N-acryloyltris(hydroxymethyl)aminomethane) CM derivative
EINECS	Contact for details

Quality Control

Our Cm-Trisacryl M is manufactured under strict quality management systems to ensure batch-to-batch consistency suitable for cGMP environments. Each lot undergoes rigorous testing for key performance parameters including ligand density, particle size distribution, and dynamic binding capacity. Certificates of Analysis (COA) documenting these specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. Avoid freezing. The product is supplied as a suspension in a preservative solution; do not allow the medium to dry out.

Specification

Item	Specification
Matrix	Macroporous Poly(N-acryloyltris(hydroxymethyl)aminomethane)
Functional Group	Carboxymethyl (CM), weak cation exchanger
Ionic Capacity	Contact for details
Particle Size	40-80 μm (mean)
Exclusion Limit	> 1x10⁷ Daltons
pH Stability	2 - 12 (operational); 2 - 14 (cleaning)
Chemical Stability	Stable in all common aqueous buffers, 1M NaOH, 30% isopropanol, 6M guanidine HCl
Maximum Pressure	0.3 MPa (3 bar, 43 psi)
Storage Solution	20% Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.