Description

3-Bromo-4-Fluoro-Benzoyl Fluoride is a high-purity, multi-functional aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents adjacent to a highly reactive acyl fluoride group, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions, fluorination chemistry, and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine and bromine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic materials, improving charge transport and thermal stability.
• Cross-Coupling Reactions: The bromine substituent acts as an excellent handle for Suzuki, Stille, and other palladium-catalyzed coupling reactions to create biaryl structures.
• Fluorination Reagent Precursor: The acyl fluoride group can be utilized to introduce fluorine atoms or fluorinated moieties into target molecules.
• Polymer Chemistry: Intermediate for synthesizing specialty polymers and high-performance resins with enhanced chemical resistance.

Basic Information

Product Name	3-Bromo-4-Fluoro-Benzoyl Fluoride
CAS No.	78239-65-3
Molecular Formula	C7H3BrF2O
Molecular Weight	220.99 g/mol
Synonyms	3-Bromo-4-fluorobenzoyl fluoride; 4-Fluoro-3-bromobenzoyl fluoride; Benzoyl fluoride, 3-bromo-4-fluoro-; 3-Bromo-4-fluorobenzoic acid fluoride; 78239-65-3; 3-Br-4-F-C6H2-C(O)F
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Fluoro-Benzoyl Fluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.