Description

2'-Deoxyadenylyl(3'5')-2'-*Deoxyguanosin E Ammonium is a high-purity dinucleotide derivative, specifically a deoxyadenylyl-deoxyguanosine ammonium salt, essential for advanced biochemical research and development. This compound serves as a critical building block and reference standard in the study of nucleic acid structure, function, and synthesis. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers working in oligonucleotide synthesis, molecular biology, and therapeutic discovery.

Application

• Oligonucleotide Synthesis: As a protected dinucleotide phosphoramidite precursor or intermediate for solid-phase synthesis of DNA sequences.
• Biochemical Research: A key reagent and reference standard for studying DNA-protein interactions, enzyme kinetics (e.g., polymerases, nucleases), and nucleic acid metabolism.
• Pharmaceutical Development: Used in the research and development of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics.
• Diagnostic Assay Development: Employed in the design and calibration of probes for PCR, qPCR, and other molecular diagnostic techniques.
• Academic Research: Fundamental tool for university and institutional labs investigating genetics, epigenetics, and structural biology.
• Quality Control: Serves as an analytical standard for the purity assessment of synthetic oligonucleotides and related products.

Basic Information

Product Name	2'-Deoxyadenylyl(3'5')-2'-*Deoxyguanosin E Ammonium
CAS No.	77710-59-9
Molecular Formula	C20H28N10O10P • xNH3
Molecular Weight	Contact for details
Synonyms	d(ApG) Ammonium Salt; Deoxyadenylyl-(3'→5')-deoxyguanosine Ammonium Salt; 2'-Deoxyadenylyl(3'-5')-2'-deoxyguanosine Ammonium; dApdG Ammonium; pd(A-G) Ammonium; Deoxyadenosine Deoxyguanosine Dinucleotide Ammonium Salt; DNA Dinucleotide d(ApG) Ammonium; Adenine Deoxyguanosine Dinucleotide Derivative
EINECS	Contact for details

Quality Control

Our 2'-Deoxyadenylyl(3'5')-2'-*Deoxyguanosin E Ammonium is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.