Description

1,25,26-Trihydroxyvitamin D3 is a biologically active metabolite of vitamin D3, representing a high-purity reference standard and pharmaceutical intermediate. This compound is critical for research and development in endocrinology and bone metabolism due to its potent role in calcium and phosphate homeostasis. It is primarily utilized by pharmaceutical manufacturers, advanced research institutions, and diagnostic kit developers focused on metabolic disorders and vitamin D pathways.

Application

• Pharmaceutical Intermediate: Key starting material or reference standard in the synthesis of advanced vitamin D analogs and metabolites for therapeutic applications.
• Biochemical Research: Used as a high-purity standard in studies investigating vitamin D receptor (VDR) activation, gene regulation, and cellular signaling pathways.
• Diagnostic Development: Serves as a critical calibrant or component in the development of immunoassays and LC-MS/MS methods for quantifying vitamin D metabolites in clinical laboratories.
• Metabolic Studies: Essential for in vitro and in vivo research on calcium homeostasis, bone mineralization, and the treatment of conditions like osteoporosis and renal osteodystrophy.
• Reference Material: Provides an authenticated standard for quality control in pharmaceutical production and for verifying the purity of related compounds.

Basic Information

Product Name	1,25,26-Trihydroxyvitamin D3
CAS No.	77372-59-9
Molecular Formula	C₂₇H₄₄O₄
Molecular Weight	432.64 g/mol
Synonyms	1α,25,26-Trihydroxycholecalciferol; 1α,25,26-Trihydroxyvitamin D₃; (1S,3R,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25,26-tetrol; 25,26-Dihydroxycalcitriol; 1,25,26-Trihydroxy Vitamin D3; 1,25,26-TriOH D3
EINECS	Contact for details

Quality Control

Our 1,25,26-Trihydroxyvitamin D3 is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with customer specifications and relevant research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at -20°C or below to minimize oxidation and ensure long-term stability. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.