Description

(S)-Indapamide CAS NO 77083-53-5 is the single enantiomer of the thiazide-like diuretic indapamide, representing a high-purity chiral building block and reference standard. This compound is of significant value for pharmaceutical research and development, particularly in the study of stereospecific drug activity and metabolism. It is essential for scientists and manufacturers in the pharmaceutical industry focused on developing enantiomerically pure active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (e.g., HPLC, LC-MS) for quality control of racemic indapamide or its (S)-enantiomer.
• Chiral Intermediate: Serves as a critical building block in the synthetic pathway for novel, enantiomerically pure cardiovascular drugs.
• Metabolic and Pharmacological Studies: Employed in preclinical research to investigate the distinct pharmacokinetic and pharmacodynamic profile of the (S)-enantiomer compared to the (R)-form or racemic mixture.
• Impurity Profiling: Essential for identifying and quantifying the (S)-enantiomer as a potential impurity in batches of the (R)-enantiomer or racemic indapamide API.
• Asymmetric Synthesis Research: Used as a model compound in developing and validating new chiral separation techniques or asymmetric catalytic processes.

Basic Information

Product Name	(S)-Indapamide
CAS No.	77083-53-5
Molecular Formula	C16H16ClN3O3S
Molecular Weight	365.83 g/mol
Synonyms	(S)-4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide; (S)-N-(2-Methyl-2,3-dihydro-1H-indol-1-yl)-4-chloro-3-sulfamoylbenzamide; (S)-(-)-Indapamide; L-Indapamide; (S)-Enantiomer of Indapamide; (1S)-4-Chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide
EINECS	Contact for details

Quality Control

Our (S)-Indapamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive (store away from light) and hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.