Description

(R)-Indapamide CAS NO 77083-52-4 is the enantiomerically pure form of the widely used antihypertensive and diuretic agent, Indapamide. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the synthesis of novel, stereospecific drug candidates where the (R)-configuration is required for targeted biological activity. It is an essential building block for medicinal chemists and pharmaceutical manufacturers focused on cardiovascular and metabolic disease therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a high-purity chiral building block for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).
• Research & Development: Critical material for pharmacological studies, structure-activity relationship (SAR) analysis, and metabolic pathway investigations of indapamide and its analogs.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Asymmetric Synthesis: Used in the development and scaling of stereoselective synthetic routes for cardiovascular drugs.
• Impurity Profiling: Employed as a marker to identify, quantify, and control the (R)-enantiomer as a potential impurity in bulk (S)-Indapamide production.

Basic Information

Product Name	(R)-Indapamide
CAS No.	77083-52-4
Molecular Formula	C16H16ClN3O3S
Molecular Weight	365.83 g/mol
Synonyms	(R)-4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide; (R)-N-(2-Methyl-2,3-dihydro-1H-indol-1-yl)-4-chloro-3-sulfamoylbenzamide; (R)-(-)-Indapamide; Dex-Indapamide; (R)-Enantiomer of Indapamide; (1R)-4-Chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide
EINECS	Contact for details

Quality Control

Our (R)-Indapamide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing full specification data, including enantiomeric excess (ee), is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.