Description

5,6-Dichloroamiloride is a high-purity, small-molecule chemical compound widely recognized as a potent and selective inhibitor of the sodium-hydrogen exchanger (NHE). This compound matters for researchers and developers in life sciences as a critical pharmacological tool for investigating ion transport mechanisms and related cellular pathways. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cardiovascular, renal, and cancer research.

Application

• Pharmacological Research: Used as a selective inhibitor of the sodium-hydrogen exchanger (NHE), particularly the NHE-1 isoform, in cellular and biochemical studies.
• Cardiovascular Research: Investigated for its potential effects on ischemia-reperfusion injury, cardiac hypertrophy, and heart failure models.
• Cancer Biology Studies: Employed to study the role of pH regulation and NHE activity in tumor cell proliferation, migration, and apoptosis.
• Renal Physiology Research: Applied in experiments exploring ion transport in kidney cells and renal tubular function.
• Neuroscience Research: Utilized to examine the role of NHE in neuronal injury, stroke models, and neuroprotection.
• Biochemical Assay Development: Serves as a reference standard and key component in developing high-throughput screening assays for drug discovery.
• Chemical Intermediate: Acts as a specialized synthetic building block for creating novel amiloride analogs and related bioactive molecules.

Basic Information

Product Name	5,6-Dichloroamiloride
CAS No.	76599-75-2
Molecular Formula	C8H6Cl2N6O
Molecular Weight	273.07 g/mol
Synonyms	5,6-Dichloroamiloride; 3,5-Diamino-6-chloro-N-(diaminomethylene)pyrazine-2-carboxamide; 5,6-Dichloroamiloride hydrochloride (if applicable); 5,6-Dichloroamiloride HCl; NHE-1 Inhibitor; Amiloride, 5,6-dichloro-; 5,6-Dichloroamiloride (free base)
EINECS	Contact for details

Quality Control

Our 5,6-Dichloroamiloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.