Description

Poly(5-Methoxycytidylic Acid) CAS NO 76528-22-8 is a synthetic polynucleotide composed of 5-methoxycytidylic acid monomers. This chemically modified nucleic acid is critical for advanced biochemical research and development, offering unique properties compared to its unmodified counterparts. It is primarily utilized by research institutions and pharmaceutical companies engaged in oligonucleotide therapeutics, molecular biology studies, and the development of novel diagnostic tools.

Application

• Oligonucleotide Synthesis & Therapeutics: Serves as a key building block for synthesizing modified antisense oligonucleotides (ASOs) and siRNA, enhancing stability and target affinity.
• Biochemical Research: Used in studies investigating nucleic acid structure, function, and protein-nucleic acid interactions where specific base modifications are required.
• Diagnostic Probe Development: Incorporated into probes for fluorescence in situ hybridization (FISH) and other molecular diagnostic assays to improve specificity and signal.
• Enzyme & Polymerase Studies: Acts as a substrate or template to study the activity, fidelity, and inhibition of DNA/RNA polymerases and nucleases.
• Aptamer Development: Utilized in the selection and engineering of modified aptamers (SELEX) for therapeutic and sensing applications with improved pharmacokinetic properties.
• Reference Standard: Functions as a high-purity analytical standard for quality control in the production of other nucleic acid-based products.

Basic Information

Product Name	Poly(5-Methoxycytidylic Acid)
CAS No.	76528-22-8
Molecular Formula	(C10H14N3O7P)n
Molecular Weight	Contact for details (Polymer)
Synonyms	Poly(5-mC); Poly(5-Methoxycytidylic acid) sodium salt; 5-Methoxycytidylic acid homopolymer; Poly(5-Methoxy-CMP); Poly(m5CMP); Poly(5-Methoxycytidine 5'-monophosphate); Poly(5-Methoxycytidylate); 5-Methoxy Poly C
EINECS	Contact for details

Quality Control

Our Poly(5-Methoxycytidylic Acid) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications such as assay/purity, chain length distribution, and absence of nucleases. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95%
Base Composition	> 98% 5-Methoxycytidine
pH (1% Solution)	6.0 - 8.0
Endotoxin	< 10 EU/mg
Solubility	Soluble in water, slightly soluble in organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.