Description

Gacyclidine is a potent and selective non-competitive NMDA receptor antagonist with significant research and development interest. This compound matters for its potential in neurological research and as a key intermediate in the synthesis of advanced pharmaceutical agents. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing treatments for conditions like stroke, neuropathic pain, and neurodegenerative diseases. Gacyclidine CAS NO 76478-45-0 is handled under controlled conditions to ensure its stability and purity for critical applications.

Application

• Neurological Research: Used as a reference standard and active compound in studies targeting NMDA receptor function, excitotoxicity, and neuroprotection.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel central nervous system (CNS) active drug candidates.
• Preclinical Development: Employed in animal models to investigate potential therapeutic efficacy for ischemic stroke, traumatic brain injury, and chronic pain.
• Biochemical Assays: Utilized in vitro to study receptor-ligand interactions and screen for new modulators of the NMDA receptor complex.
• Reference Material: Provides a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.

Basic Information

Product Name	Gacyclidine
CAS No.	76478-45-0
Molecular Formula	C17H25N
Molecular Weight	243.39 g/mol
Synonyms	GK-11; CI-979; TCP; Tenocyclidine; (1-[1-(2-Thienyl)cyclohexyl]piperidine); 1-(1-(Thiophen-2-yl)cyclohexyl)piperidine; 2-Thienylcyclohexylpiperidine; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Every batch of our Gacyclidine is produced and tested under strict quality management systems. We ensure compliance with high-purity standards suitable for research and development applications. Comprehensive testing includes identity confirmation, purity assay, and impurity profiling. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and product integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and protected from light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.