Description

Tri-(Deoxyguanylic Acid-Deoxycytidylic Acid) CAS NO 76186-50-0 is a defined-sequence oligonucleotide, specifically a trimer composed of alternating deoxyguanylic and deoxycytidylic acid residues. This compound serves as a critical building block and reference standard in nucleic acid research and therapeutic development. It is essential for scientists and manufacturers in the fields of molecular biology, diagnostics, and oligonucleotide-based pharmaceuticals who require high-purity, well-characterized short DNA sequences for their work.

Application

• Oligonucleotide Synthesis: Used as a precursor or intermediate in the solid-phase synthesis of longer, custom DNA strands for research and therapeutic applications.
• Molecular Biology Research: Serves as a primer, probe, or model compound in PCR, sequencing, hybridization studies, and structural analysis of nucleic acids.
• Pharmaceutical Development: Acts as a critical starting material or reference standard in the development of antisense oligonucleotides, siRNA, aptamers, and other gene-targeting therapies.
• Diagnostic Assay Development: Employed in the design and calibration of diagnostic kits for genetic testing, pathogen detection, and biomarker identification.
• Biochemical Studies: Utilized to study DNA-protein interactions, enzyme kinetics (e.g., with nucleases or polymerases), and the fundamentals of nucleic acid chemistry.
• Quality Control & Standardization: Functions as an analytical standard for purity assessment, method validation, and ensuring batch-to-batch consistency in oligonucleotide production.

Basic Information

Product Name	Tri-(Deoxyguanylic Acid-Deoxycytidylic Acid)
CAS No.	76186-50-0
Molecular Formula	C30H38N15O19P3
Molecular Weight	977.62 g/mol
Synonyms	d(GpCpG); Deoxyguanylyl-(3'→5')-deoxycytidylyl-(3'→5')-deoxyguanosine; GpCpG trimer; 5'-d(GCG)-3'; Oligodeoxyribonucleotide d(GCG); DNA trimer GCG; Deoxyribonucleoside Triphosphate Trimer; Guanosine-cytidine-guanosine oligonucleotide
EINECS	Contact for details

Quality Control

Our Tri-(Deoxyguanylic Acid-Deoxycytidylic Acid) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and tests for moisture and endotoxin levels where specified. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage under inert atmosphere, please contact us.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Extinction Coefficient (ε260)	Contact for details
Molecular Weight (MS)	977.62 ± 2 Da

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.