Description

Deacylpolymyxin B is a modified derivative of the polymyxin B antibiotic, characterized by the removal of the fatty acyl tail from its peptide structure. This modification alters its biological activity and physicochemical properties, making it a valuable intermediate and reference standard in pharmaceutical research and development. It is primarily utilized by research institutions, pharmaceutical manufacturers, and quality control laboratories engaged in the study of antimicrobial peptides, novel antibiotic development, and analytical method validation. The compound is supplied under stringent quality controls to ensure batch-to-batch consistency for critical applications.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, purity assessment, and quantification of polymyxin derivatives in analytical methods like HPLC and mass spectrometry.
• Antimicrobial Research: Serves as a key intermediate or tool compound in structure-activity relationship (SAR) studies to develop new polymyxin-based antibiotics with improved efficacy and reduced toxicity.
• Biochemical Research: Employed in studies investigating the mechanism of action of polymyxins against Gram-negative bacteria, particularly regarding membrane disruption.
• Quality Control (QC) Testing: Essential for the assay and impurity profiling of polymyxin B active pharmaceutical ingredients (APIs) and finished drug products in pharmaceutical manufacturing.
• Method Development & Validation: Critical for developing and validating chromatographic and spectroscopic methods in compliance with ICH and pharmacopeial guidelines (USP, EP).

Basic Information

Product Name	Deacylpolymyxin B
CAS No.	76014-40-9
Molecular Formula	C44H85N16O13
Molecular Weight	1022.3 g/mol
Synonyms	Polymyxin B Nonapeptide; Polymyxin B Des-fatty Acid; Colistin Nonapeptide (related); Demyristoylpolymyxin B; PMBN; Deacylated Polymyxin B; Antibiotic Aerosporin Derivative; N-[4-amino-1-[[1-[[4-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]butyl]carbamoyl]-2-methylbutyl]carbamoyl]butyl]-2,4-diaminobutanamide
EINECS	Contact for details

Quality Control

Our Deacylpolymyxin B is manufactured and tested under a quality management system to ensure it meets the exacting standards required for pharmaceutical research. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While specific grades can be tailored, our standard material is suitable for use as a laboratory reference standard and is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm structure and potency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with molecular structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Bacterial Endotoxins	< 10.0 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.