Description

Colistin Heptapeptide is a defined cyclic peptide component of the polymyxin antibiotic colistin. This high-purity reference standard is critical for analytical research, quality control, and the development of novel antimicrobial agents. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and academic institutions engaged in antibiotic research and resistance studies.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the identification, assay, and impurity profiling of colistin sulfate and related pharmaceutical products via HPLC, LC-MS, and other analytical methods.
• Antimicrobial Research: Serves as a key intermediate or model compound in studies investigating the mechanism of action, structure-activity relationships (SAR), and resistance mechanisms of polymyxin antibiotics.
• Biochemical Research: Employed in microbiological and biochemical assays to study bacterial membrane interactions and the effects of cationic peptides.
• Quality Control (QC) & Assurance: Essential for in-house QC testing in API (Active Pharmaceutical Ingredient) manufacturing to ensure batch consistency and compliance with pharmacopeial specifications (e.g., USP, EP).
• Method Development & Validation: Critical for developing and validating new analytical methods in regulatory and compliance laboratories.
• Academic Research: Used in university and institutional research projects focused on infectious diseases, medicinal chemistry, and peptide science.

Basic Information

Product Name	Colistin Heptapeptide
CAS No.	75748-25-3
Molecular Formula	C42H78N12O10
Molecular Weight	911.15 g/mol
Synonyms	Colistin Heptapeptide; Cyclo[Dab-Dab-Dab-D-Leu-Dab-Dab-Thr]; Polymyxin E Heptapeptide; Colistin A Heptapeptide; [Thr1,D-Leu4]-Polymyxin E1 Heptapeptide; Antibiotic A1 Heptapeptide; N-[(2S,3R)-1-[[(2S)-6-Amino-1-[[(2S,3R)-1-[[(2S)-6-Amino-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-6-Amino-1-[[(2S,3R)-1-[[(2S)-2-Amino-3-hydroxybutanoyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-[(3S)-3-hydroxybutyl]amino]butan-2-yl]-L-α,γ-diaminobutyryl-L-α,γ-diaminobutyryl-L-α,γ-diaminobutyryl-D-leucyl-L-α,γ-diaminobutyryl-L-α,γ-diaminobutyryl-O-(3-hydroxy-L-threonine) Cyclic Peptide
EINECS	Contact for details

Quality Control

Our Colistin Heptapeptide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets high-purity reference standard requirements. Certificates of Analysis (COA) with detailed chromatographic data are provided and traceable to a primary reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.