Description

1,4,8-Trideoxy-1,4-Dihydro-1,4-Dioxorifamycin is a key semi-synthetic derivative of the rifamycin class of antibiotics, valued for its role as a crucial intermediate in advanced pharmaceutical synthesis. This compound is engineered to provide a specific chemical scaffold for developing next-generation antimicrobial agents targeting resistant bacterial strains. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel anti-tuberculosis and anti-MRSA therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced rifamycin analogs and novel antibiotic candidates.
• Antimicrobial Research: Used in biochemical and microbiological research to study structure-activity relationships (SAR) and mechanisms of action against Gram-positive bacteria.
• API Development: Serves as a precursor in the development and scale-up of new Active Pharmaceutical Ingredients (APIs) for treating tuberculosis and other bacterial infections.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and impurity profiling.
• Bioconjugation Studies: Utilized in research exploring targeted drug delivery systems through chemical modification of the rifamycin core.

Basic Information

Product Name	1,4,8-Trideoxy-1,4-Dihydro-1,4-Dioxorifamycin
CAS No.	75352-22-6
Molecular Formula	C38H47NO13
Molecular Weight	725.78 g/mol
Synonyms	1,4,8-Trideoxy-1,4-dihydro-1,4-dioxorifamycin; 1,4,8-Trideoxy-1,4-dihydro-1,4-dioxo-rifamycin; Rifamycin derivative 75352-22-6; 3-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin; 1,4,8-Trideoxy-1,4-dihydro-1,4-dioxorifamycin S; A semi-synthetic rifamycin intermediate.
EINECS	Contact for details

Quality Control

Our 1,4,8-Trideoxy-1,4-Dihydro-1,4-Dioxorifamycin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.