Description

8-Deoxy-30-Hydroxyrifamycin W is a significant semi-synthetic derivative of the rifamycin class of antibiotics, identified by CAS No. 75352-18-0. This compound is valued for its role as a key intermediate in the research and development of novel antimicrobial agents, particularly in the synthesis of more potent and targeted rifamycin analogs. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on combating drug-resistant bacterial infections and developing new therapeutic solutions.

Application

• Pharmaceutical Intermediate: Critical starting material or intermediate in the synthesis of advanced rifamycin-based antibiotics.
• Antimicrobial Research: Used in biochemical and microbiological research to study structure-activity relationships (SAR) and mechanisms of action against bacteria.
• Drug Discovery & Development: Serves as a scaffold for the development of new compounds targeting multidrug-resistant (MDR) pathogens like Mycobacterium tuberculosis.
• Reference Standard: Employed as a high-purity analytical standard in quality control and method development for related pharmaceutical products.
• Biochemical Tool: Utilized in enzymatic studies, particularly those involving bacterial RNA polymerase inhibition.

Basic Information

Product Name	8-Deoxy-30-Hydroxyrifamycin W
CAS No.	75352-18-0
Molecular Formula	C38H47NO12
Molecular Weight	709.78 g/mol
Synonyms	8-Deoxy-30-hydroxy-rifamycin W; Rifamycin W, 8-deoxy-30-hydroxy-; 30-Hydroxy-8-deoxyrifamycin W; (12Z,14E,24E)-(2S,12S,13S,14R,15R,16S,17R,18R,19S,20S,21S,22R,23S,26R,28S,30S,31S,32S)-30-Hydroxy-5,6,9,17,29-pentahydroxy-11-methoxy-3,7,15,21,25-pentamethyl-26-(2-methyl-1-oxopropoxy)-1-oxa-6-azacyclohexacosa-3,12,14,24-tetraene-2,13,23-trione; Antibiotic X 149; Antibiotic X-149
EINECS	Contact for details

Quality Control

Our 8-Deoxy-30-Hydroxyrifamycin W is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is light-sensitive and easily oxidized; for long-term storage, consider under an inert atmosphere (e.g., nitrogen or argon) in a desiccated environment to maintain stability.

Specification

Item	Specification
Appearance	Orange to reddish-brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.