Description

8,25,34A-Trideoxy-25,34A-Epoxy-34A-Oxorifamycin W is a semi-synthetic derivative of the rifamycin class of antibiotics, characterized by its unique epoxy-oxo structural modifications. This compound is a critical intermediate in the research and development of novel antimicrobial agents, particularly for targeting drug-resistant bacterial strains. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of advanced antibiotic candidates and for conducting structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of next-generation rifamycin-based antibiotics.
• Antimicrobial Research: Used in biochemical and microbiological research to study mechanisms of action against bacterial RNA polymerase.
• Structure-Activity Relationship (SAR) Studies: Essential for medicinal chemistry programs aiming to optimize potency and pharmacokinetic properties of rifamycin analogs.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Fine Chemical Synthesis: Utilized in multi-step organic synthesis for creating specialized chemical libraries for screening.

Basic Information

Product Name	8,25,34A-Trideoxy-25,34A-Epoxy-34A-Oxorifamycin W
CAS No.	75352-16-8
Molecular Formula	C38H47NO12
Molecular Weight	709.78 g/mol
Synonyms	8,25,34A-Trideoxy-25,34A-epoxy-34A-oxorifamycin W; (12Z,14E,24E)-(2S,12S,13S,14R,15S,16S,17S,18R,19S,20R,21S,22R,23S,26R)-13,23-Epoxy-2-ethanoyloxy-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,15,17,21,23-heptamethyl-1,11-dioxo-1,11-dihydro-2H-26-epoxy[1,11]dioxacyclotetradecino[2,1-b:13,14-b']difuran-8-yl acetate; Rifamycin W, 8,25,34A-trideoxy-25,34A-epoxy-34A-oxo-; 25,34A-Epoxy-8,25,34A-trideoxy-34A-oxorifamycin W
EINECS	Contact for details

Quality Control

Our 8,25,34A-Trideoxy-25,34A-Epoxy-34A-Oxorifamycin W is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.