Description

Chlorthalidone CAS NO 74666-82-3 is a high-purity, long-acting thiazide-like diuretic and antihypertensive agent. It is a critical active pharmaceutical ingredient (API) valued for its efficacy in managing fluid retention and high blood pressure. This compound is essential for pharmaceutical manufacturers and research institutions developing and producing cardiovascular medications. Consistent quality and reliable supply are paramount for ensuring the safety and effectiveness of the final drug products.

Application

• Primary Pharmaceutical Ingredient: Core API in the formulation of antihypertensive and diuretic tablets and capsules.
• Cardiovascular Disease Management: Used in medications for the treatment of essential hypertension (high blood pressure).
• Edema Control: Employed in therapies for edema associated with congestive heart failure, hepatic cirrhosis, and renal dysfunction.
• Fixed-Dose Combination Drugs: A key component in combination therapies with other antihypertensive agents like β-blockers or ACE inhibitors.
• Pharmaceutical Research & Development: Serves as a reference standard and starting material in preclinical and clinical research for new cardiovascular treatments.
• Generic Drug Manufacturing: A vital bulk substance for the production of cost-effective generic versions of branded diuretic medications.

Basic Information

Product Name	Chlorthalidone
CAS No.	74666-82-3
Molecular Formula	C14H11ClN2O4S
Molecular Weight	338.77 g/mol
Synonyms	Chlorthalidone; 2-Chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzenesulfonamide; Hygroton; Thalitone; Oxodolin; Uridon; Uridur; G-33182; IUPAC: 2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide
EINECS	Contact for details

Quality Control

Our Chlorthalidone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with major pharmacopeial standards such as USP and EP. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.