Description

(+)-Hygroton CAS NO 74658-81-4 is the optically active enantiomer of the diuretic agent chlorthalidone, a key pharmaceutical intermediate. This high-purity chiral building block is critical for the development and manufacturing of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and production facilities focused on cardiovascular and antihypertensive medications, where stereochemical purity directly impacts therapeutic efficacy and safety profiles.

Application

• Pharmaceutical Intermediate: Primary use as a chiral synthon in the synthesis of enantiopure chlorthalidone and related diuretic APIs.
• Research & Development: Critical reference standard and starting material for pharmacological studies, metabolic pathway analysis, and stereochemistry research.
• Process Chemistry: Used in route development and scale-up for the production of single-enantiomer cardiovascular drugs.
• Analytical Standard: Serves as a high-purity calibrant for HPLC, LC-MS, and chiral separation methods in quality control laboratories.
• Regulatory Submissions: Provides the necessary enantiomerically pure material for impurity profiling and stability studies required by FDA, EMA, and other agencies.

Basic Information

Product Name	(+)-Hygroton
CAS No.	74658-81-4
Molecular Formula	C14H11ClN2O4S
Molecular Weight	338.77 g/mol
Synonyms	(+)-Chlorthalidone; (R)-(+)-Chlorthalidone; (3R)-2-Chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzenesulfonamide; Hygroton; Chlorthalidone enantiomer; IG-63; SR 720-22
EINECS	Contact for details

Quality Control

Our (+)-Hygroton is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment. We adhere to cGMP principles where applicable to support our global customer base in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. The container should be kept tightly sealed when not in use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.