Description

(-)-Hygroton CAS NO 74658-80-3 is the specific enantiomer of the diuretic compound chlorthalidone, known for its high purity and defined stereochemistry. This compound is of critical importance in pharmaceutical research and development, particularly for studying stereospecific biological activity and pharmacokinetics. It is primarily needed by research institutions, pharmaceutical companies, and fine chemical suppliers engaged in the development of cardiovascular therapeutics, analytical method development, and as a reference standard.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for quality control and analytical method validation in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key chiral building block in the synthesis of enantiomerically pure diuretic and antihypertensive drugs.
• Biochemical Research: Employed in pharmacological studies to investigate the stereospecific binding and mechanism of action of thiazide-like diuretics.
• Analytical Chemistry: Utilized as an internal standard or calibration compound in chromatographic (HPLC, LC-MS) analyses for quantitative assays.
• Formulation Development: Applied in pre-formulation studies for developing novel drug delivery systems targeting specific enantiomeric effects.

Basic Information

Product Name	(-)-Hygroton
CAS No.	74658-80-3
Molecular Formula	C14H11ClN2O4S
Molecular Weight	338.77 g/mol
Synonyms	(-)-Chlorthalidone; (R)-Chlorthalidone; (3R)-3-(4-Chloro-3-sulfamoylphenyl)-3-hydroxy-1-isobenzofuranone; Hygroton (enantiomer); 2-Chloro-5-(1-hydroxy-3-oxo-1-isobenzofuran-1-yl)benzenesulfonamide; Chlorthalidone (-)-enantiomer; CL 36673
EINECS	Contact for details

Quality Control

Our (-)-Hygroton is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, to ensure it meets stringent specifications for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, Chiral HPLC) are provided to guarantee identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% enantiomeric excess
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.