Description

Methiothepin Mesylate is a potent and selective serotonin 5-HT1 receptor antagonist, widely utilized as a critical pharmacological research tool. Its primary value lies in its ability to selectively block 5-HT1 receptor subtypes, making it indispensable for studying serotonergic pathways in the central nervous system. This compound is essential for researchers and developers in neuropharmacology, drug discovery, and the development of treatments for neurological and psychiatric disorders.

Application

• Neuropharmacological Research: A key tool for investigating the function and distribution of serotonin 5-HT1 receptor subtypes in the brain.
• Drug Discovery & Development: Used in high-throughput screening and target validation studies for novel CNS-active pharmaceuticals.
• Behavioral Studies: Employed in preclinical models to elucidate the role of 5-HT1 receptors in anxiety, depression, and other behaviors.
• Biochemical Assays: Serves as a reference standard in receptor binding and functional assays (e.g., cAMP inhibition).
• Academic & Institutional Research: Fundamental for university and government lab studies on serotonin signaling mechanisms.
• Reference Standard: Used for quality control and method development in analytical laboratories.

Basic Information

Product Name	Methiothepin Mesylate
CAS No.	74611-28-2
Molecular Formula	C20H26N2O3S2
Molecular Weight	406.56 g/mol
Synonyms	Methiothepin Mesylate; Methiothepin Methanesulfonate; 5-HT1 Antagonist; Serotonin 5-HT1 Receptor Antagonist; 10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl 1-piperazinepropionate methanesulfonate; Methiothepin maleate (related salt); Ro 8-6837 (historical code)
EINECS	Contact for details

Quality Control

Our Methiothepin Mesylate is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable and reproducible results for your scientific work.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.