Description

Methyl (E)-3-Fluorocinnamate CAS NO 74325-03-4 is a high-purity fluorinated cinnamate ester, a versatile building block in advanced organic synthesis. Its core value lies in the strategic incorporation of a fluorine atom into the aromatic ring, which can significantly alter the electronic properties, metabolic stability, and bioavailability of target molecules. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries seeking to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in protease inhibitors, kinase inhibitors, and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated mesogens and charge-transport materials, improving the performance and stability of electronic displays.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart unique optical, surface, or durability characteristics.
• Chemical Biology Probes: Utilized in the synthesis of fluorinated probes for studying enzyme mechanisms and protein-ligand interactions.
• Flavor & Fragrance Chemistry: Acts as an intermediate for creating novel synthetic aromatic compounds with modified scent profiles.

Basic Information

Item	Detail
Product Name	Methyl (E)-3-Fluorocinnamate
CAS No.	74325-03-4
Molecular Formula	C10H9FO2
Molecular Weight	180.17 g/mol
Synonyms	(E)-Methyl 3-fluorocinnamate; Methyl (E)-3-fluorocinnamate; Methyl trans-3-fluorocinnamate; 3-Fluorocinnamic acid methyl ester; (E)-3-Fluorocinnamic acid methyl ester; Methyl (E)-3-fluorobenzeneacrylate; Methyl (E)-3-fluoro-3-phenylacrylate
EINECS	Contact for details

Quality Control

Our Methyl (E)-3-Fluorocinnamate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and isomer conformity. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Isomeric Purity ((E)-isomer)	≥ 99.0% (by HPLC or GC)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.