Description

n-Propionylampicillin is a semi-synthetic penicillin derivative, specifically a prodrug form of ampicillin. This compound is of significant value in pharmaceutical research and development, offering enhanced stability and bioavailability profiles for targeted therapeutic applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology industries for the synthesis of advanced antibiotic formulations and in preclinical studies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel β-lactam antibiotics and prodrugs.
• Antibacterial Research: Used in R&D for studying structure-activity relationships (SAR) and developing new antibacterial agents with improved efficacy.
• Prodrug Development: Serves as a model compound for designing prodrugs that enhance the oral absorption and metabolic stability of ampicillin.
• Analytical Reference Standard: Employed as a high-purity standard in quality control (QC) and analytical testing (HPLC, LC-MS) within pharmaceutical manufacturing.
• Bioconjugation Studies: Utilized in research exploring the conjugation of antibiotics to carriers or other molecules for targeted drug delivery.

Basic Information

Product Name	n-Propionylampicillin
CAS No.	74226-27-0
Molecular Formula	C19H23N3O6S
Molecular Weight	421.47 g/mol
Synonyms	Propionyl Ampicillin; Ampicillin Propionate; D-(-)-α-Aminobenzylpenicillin Propionate; (2S,5R,6R)-6-[[(2R)-2-Amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Propionate; Ampicillin N-Propionate Ester; SQ 11,324
EINECS	Contact for details

Quality Control

Our n-Propionylampicillin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and tests for residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) are available upon request to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.