Description

(-)-Bremazocine Hydrochloride CAS NO 74100-60-0 is a potent and selective κ-opioid receptor (KOR) agonist, widely recognized for its high affinity and specificity in pharmacological research. This compound is a critical tool for studying opioid receptor function, neuropathic pain mechanisms, and the development of novel analgesic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience and drug discovery.

Application

• Neuroscience Research: A key pharmacological tool for investigating the role of κ-opioid receptors in the central nervous system.
• Analgesic Development: Used in preclinical studies to model and evaluate novel non-addictive pain relief pathways and compounds.
• Behavioral Pharmacology: Employed in studies exploring the effects of KOR activation on mood, stress response, and reward systems.
• Receptor Binding Assays: Serves as a high-affinity reference standard in competitive binding experiments to characterize new ligands.
• Signal Transduction Studies: Used to study downstream cellular signaling pathways activated by κ-opioid receptor agonism.
• Toxicology & Safety Pharmacology: Applied in profiling the physiological effects and potential side-effect profiles of KOR-targeting drug candidates.

Basic Information

Product Name	(-)-Bremazocine Hydrochloride
CAS No.	74100-60-0
Molecular Formula	C₂₅H₃₂N₂O₃ • HCl
Molecular Weight	445.00 g/mol (Free base: 408.54 g/mol)
Synonyms	Bremazocine HCl; (-)-Bremazocine HCl; (2S)-2-[(5R,6R,8R,14S)-17-Cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-N,N-diethyl-3,3-dimethylbutanamide Hydrochloride; 17-Cyclopropylmethyl-4,5α-epoxy-6β,14-ethano-3-hydroxy-6β-methoxy-7α-[3,3-dimethyl-2-(N,N-diethylbutyramido)]butylmorphinan Hydrochloride; C-16,048; C 16048
EINECS	Contact for details

Quality Control

Our (-)-Bremazocine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.