Description

N2-[n-(3-Hydroxy-8-Methyl-1-Oxononyl)-D-Ser-]Cyclo[L-Dab*-L-Dab-D-Leu-L-Leu-L-Dab-L-Dab-L-Leu-] is a complex, high-purity cyclic peptide derivative, also known as a lipopeptide antibiotic precursor. This compound matters for its role as a key intermediate in the synthesis of advanced antimicrobial agents, particularly in the daptomycin family, which are critical for treating serious Gram-positive bacterial infections. It is essential for pharmaceutical R&D laboratories, process chemists, and manufacturers focused on developing and producing next-generation antibiotic therapies. The compound is supplied under strict quality control to ensure batch-to-batch consistency for critical synthetic pathways.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the total synthesis of lipopeptide antibiotics like daptomycin and related analogs.
• Antimicrobial Research: Serves as a reference standard and starting material in biochemical research to study structure-activity relationships (SAR) of cyclic lipopeptides.
• Process Development: Used in scaling up and optimizing fermentation or synthetic routes for complex peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation Studies: Potential utility in developing peptide-drug conjugates or labeled probes for diagnostic and therapeutic applications.
• Academic & Institutional Research: Employed in university and institutional labs for fundamental studies in medicinal chemistry, microbiology, and peptide science.

Basic Information

Item	Details
Product Name	N2-[n-(3-Hydroxy-8-Methyl-1-Oxononyl)-D-Ser-]Cyclo[L-Dab*-L-Dab-D-Leu-L-Leu-L-Dab-L-Dab-L-Leu-]
CAS No.	73984-54-0
Molecular Formula	C73H122N14O19
Molecular Weight	1499.8 g/mol (approx.)
Synonyms	Daptomycin Precursor; Cyclic Lipopeptide Intermediate; A21978C Factor; (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-6-Amino-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-6-Amino-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid; A21978C0.
EINECS	Contact for details

Quality Control

Every batch of our N2-[n-(3-Hydroxy-8-Methyl-1-Oxononyl)-D-Ser-]Cyclo[L-Dab*-L-Dab-D-Leu-L-Leu-L-Dab-L-Dab-L-Leu-] is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to support its use in regulated environments, including a detailed Certificate of Analysis (COA) with results from HPLC, MS, and NMR. Our quality protocols are designed to meet the stringent requirements for pharmaceutical intermediates, ensuring high purity, correct stereochemistry, and minimal impurities.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled under a dry, inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Specific Rotation	Contact for details
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.