Description

4-Hydroxy Triamterene Sulfate, Sodium Salt is a key pharmaceutical intermediate and reference standard derived from the diuretic agent triamterene. This compound matters for its critical role in the synthesis, analytical method development, and quality control of related active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug development and regulatory compliance.

Application

• Pharmaceutical Intermediate: Used in the synthesis and scale-up production of triamterene-based diuretic drugs and their derivatives.
• Analytical Reference Standard: Serves as a high-purity standard for HPLC, LC-MS, and other chromatographic methods in pharmaceutical quality control labs.
• Metabolite Studies: Employed in pharmacokinetic and drug metabolism research to study the metabolic pathways of triamterene.
• Impurity Profiling: Critical for identifying and quantifying process-related impurities and degradation products in API batches.
• Regulatory Compliance & Documentation: Supports regulatory filings (e.g., with FDA, EMA) by providing characterized materials for stability studies and method validation.
• Research & Development: Utilized in academic and industrial R&D for exploring new therapeutic applications or formulations.

Basic Information

Product Name	4-Hydroxy Triamterene Sulfate, Sodium Salt
CAS No.	73756-87-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	4-Hydroxytriamterene sulfate sodium salt; Sodium 4-hydroxytriamterene sulfate; Triamterene metabolite sulfate sodium salt; 2,4,7-Triamino-6-(p-hydroxyphenyl)pteridine sulfate sodium salt derivative
EINECS	Contact for details

Quality Control

Our 4-Hydroxy Triamterene Sulfate, Sodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to support your quality and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.