Description

Naloxazone CAS NO 73674-85-8 is a potent and selective opioid receptor antagonist, specifically known for its long-acting properties at the mu-opioid receptor. This compound is a critical research tool for studying opioid receptor pharmacology, neurobiology, and the mechanisms of addiction and analgesia. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and contract research organizations (CROs) engaged in neuroscience and drug discovery programs.

Application

• Neuroscience Research: Used as a selective, long-duration antagonist to block mu-opioid receptors in studies of pain pathways, reward systems, and addiction mechanisms.
• Pharmacological Profiling: Essential for in vitro and in vivo assays to characterize new opioid ligands and understand receptor binding kinetics and functional activity.
• Drug Discovery & Development: Serves as a reference standard and tool compound in the screening and development of novel analgesics with reduced abuse potential.
• Academic Studies: Employed in university and institutional research to investigate the physiological and behavioral effects of opioid receptor blockade.
• Toxicology Studies: Used in research exploring opioid overdose and the development of long-acting antidotes or treatment strategies.

Basic Information

Product Name	Naloxazone
CAS No.	73674-85-8
Molecular Formula	C₁₉H₂₁NO₄
Molecular Weight	327.38 g/mol
Synonyms	Naloxazone; 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrazone; NIH 8669; 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrazone; Naloxone hydrazone; 6-Hydrazinonaloxone; 4,5α-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrazone
EINECS	Contact for details

Quality Control

Our Naloxazone is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable and reproducible results for your scientific work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.