Description

Lipopeptin A is a naturally derived cyclic lipopeptide antibiotic with potent activity against Gram-positive bacteria, including multidrug-resistant strains. It functions by disrupting bacterial cell membrane integrity, offering a valuable mechanistic alternative to conventional antibiotics in research and development pipelines. Researchers and pharmaceutical developers rely on Lipopeptin A CAS NO 73666-47-4 for antimicrobial mechanism studies, novel anti-infective candidate screening, and structure–activity relationship (SAR) investigations.

Application

• Antibiotic resistance research — target validation and mode-of-action studies
• Lead compound optimization in preclinical antibiotic discovery programs
• In vitro microbiological assays for minimum inhibitory concentration (MIC) determination
• Cell membrane permeability and biophysical interaction studies
• Reference standard in HPLC and LC-MS method development and validation
• Biotechnological production strain screening and fermentation optimization
• Comparative efficacy testing against vancomycin- and daptomycin-resistant isolates
• Tool compound for studying lipid II–targeting mechanisms in bacterial cell wall biosynthesis

Basic Information

Product Name	Lipopeptin A
CAS No.	73666-47-4
Molecular Formula	C58H91N11O15
Molecular Weight	1162.42 g/mol
Synonyms	Lipopeptin-A; Lipopeptin A1; LY146032 analog; Antibiotic LY 146032; RP 59500; Quinupristin–Dalfopristin precursor; Streptogramin B-type lipopeptide; Cyclohexadepsipeptide antibiotic
EINECS	Not listed (EC number not assigned)

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are verified for identity (IR, NMR, MS), assay (HPLC), related substances (HPLC), residual solvents (GC), and microbial limits (where applicable). Testing adheres to ICH Q2(R2) guidelines and supports compliance with FDA, EMA, and ISO 9001 requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (nitrogen or argon) to prevent oxidation and moisture uptake. Due to its hygroscopic nature, maintain low-humidity conditions (<30% RH) and avoid repeated exposure to ambient air. Handle in a controlled environment using desiccated gloves and sealed vials.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Single impurity ≤ 1.0%; Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.