Description

Thromboxane A2, Carbocyclic is a stable, synthetic carbocyclic analog of the potent endogenous prostanoid thromboxane A2 (TXA2). This compound serves as a crucial pharmacological tool and reference standard for studying the role of TXA2 in platelet aggregation, vasoconstriction, and related cardiovascular and inflammatory pathways. It is essential for researchers and developers in pharmaceutical R&D, biochemistry, and life sciences who require high-purity, well-characterized compounds for receptor binding studies, assay development, and mechanistic investigations.

Application

• Pharmacological Research: Used as a stable TXA2 mimetic in receptor binding assays and functional studies to investigate thromboxane receptor (TP receptor) signaling and antagonism.
• Cardiovascular Disease Modeling: Employed in vitro and ex vivo to model and study pathological processes like thrombosis, atherosclerosis, and vasospasm.
• Platelet Function Studies: A key agent for inducing and measuring platelet aggregation in research focused on antiplatelet drug discovery and hematology.
• Biochemical Reference Standard: Serves as an analytical standard for the identification and quantification of TXA2 pathway metabolites in complex biological matrices.
• Drug Discovery & Development: Utilized in high-throughput screening (HTS) campaigns and lead optimization programs targeting the TP receptor for novel therapeutics.
• Inflammatory Pathway Analysis: Applied in research exploring the role of eicosanoids in inflammation, bronchoconstriction, and immune response modulation.

Basic Information

Product Name	Thromboxane A2, Carbocyclic
CAS No.	73543-47-2
Molecular Formula	C21H34O5
Molecular Weight	366.5 g/mol
Synonyms	Carbocyclic Thromboxane A2; 9,11-Epithio-11,12-methano-TXA2; 9,11-Epithio-11,12-methanothromboxane A2; STA2; Carbocyclic TXA2; (1S,2S,3S,5S,6R,7S)-7-[(1E,3S)-3-Hydroxyoct-1-en-1-yl]-6-[(1S,2E)-3-(3-hydroxyprop-1-en-2-yl)-2-oxiraneyl]-2,3-dihydroxybicyclo[3.3.0]octan-4-one; SQ 28,668; SQ-28668
EINECS	Contact for details

Quality Control

Every batch of Thromboxane A2, Carbocyclic is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing results from advanced analytical techniques including HPLC, NMR, and mass spectrometry. Our quality commitment aligns with the standards expected for pharmaceutical reference standards and biochemical research reagents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.