Description

Lofexidine Hcl CAS NO 73372-53-9 is a high-purity pharmaceutical active ingredient, specifically an α-2 adrenergic receptor agonist. This compound is of critical importance for its established role in managing opioid withdrawal symptoms, offering a non-opioid therapeutic pathway. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of addiction treatment medications and neurological research.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of prescription medications for opioid detoxification and withdrawal management.
• Neurological Research: Used in preclinical and clinical studies to investigate adrenergic pathways and their modulation.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Formulation Development: Employed in R&D for creating new dosage forms such as tablets or extended-release formulations.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of finished drug products.

Basic Information

Product Name	Lofexidine Hcl
CAS No.	73372-53-9
Molecular Formula	C11H12Cl2N2O • HCl
Molecular Weight	295.59 g/mol
Synonyms	Lofexidine Hydrochloride; 2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole Hydrochloride; BritLofex; LXM-11; KA-1053; Lu AA27122
EINECS	Contact for details

Quality Control

Our Lofexidine Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.