Description

Morphinan-6-One, 17-(Cyclopropylmethyl)-3,14-Dihydroxy-, Methanesulfonate, L- is a high-purity pharmaceutical intermediate and reference standard of significant commercial and research importance. This compound, with CAS number 73361-72-5, is a key derivative in the synthesis and analytical profiling of potent opioid receptor ligands. It is essential for pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers engaged in the development of specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of advanced opioid analgesics and related therapeutic agents.
• Analytical Reference Standard: Used for method development, validation, and quality control (QC) testing in HPLC, GC-MS, and other chromatographic systems to ensure API purity and identity.
• Pharmacological Research: Serves as a precursor or standard in studies investigating opioid receptor binding affinity, structure-activity relationships (SAR), and metabolic pathways.
• Impurity Profiling: Employed as a certified reference material (CRM) to identify, quantify, and control process-related impurities and degradation products in final drug substances.
• Custom Synthesis: A starting material for the preparation of novel analogs and derivatives in medicinal chemistry programs targeting central nervous system (CNS) disorders.
• Regulatory Compliance: Provides essential material for generating data to support regulatory filings (e.g., FDA, EMA) for new drug applications (NDAs) and abbreviated new drug applications (ANDAs).

Basic Information

Product Name	Morphinan-6-One, 17-(Cyclopropylmethyl)-3,14-Dihydroxy-, Methanesulfonate, L-
CAS No.	73361-72-5
Molecular Formula	C21H27NO6S
Molecular Weight	421.51 g/mol
Synonyms	L-Noroxymorphone Cyclopropylmethyl Methanesulfonate; 17-Cyclopropylmethyl-3,14-dihydroxy-4,5α-epoxy-6-oxomorphinan Methanesulfonate; Noroxymorphone Cyclopropylmethyl Mesylate; L-Noroxymorphone CPM Mesylate; 4,5α-Epoxy-3,14-dihydroxy-17-(cyclopropylmethyl)morphinan-6-one methanesulfonate; (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one methanesulfonate
EINECS	Contact for details

Quality Control

Our Morphinan-6-One, 17-(Cyclopropylmethyl)-3,14-Dihydroxy-, Methanesulfonate, L- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates and reference standards. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), chromatographic profile, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.