Description

Vasopressin, (5-(N(4),N(4)-Dimethyl-Asn)-8-Lys)- is a synthetic analogue of the endogenous neurohypophysial hormone arginine vasopressin, specifically modified at positions 5 and 8. This compound is of significant interest for its potent and selective pharmacological activity, primarily as a V2 receptor agonist. It is essential for advanced pharmaceutical research and development, particularly in the fields of endocrinology, nephrology, and metabolic disorder therapeutics, where precise receptor targeting is required.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (HPLC, MS) for quality control of drug substances and formulations.
• Biomedical Research: Critical tool for studying the structure-activity relationships (SAR) of vasopressin receptor subtypes (V1a, V1b, V2) in vitro and in vivo.
• Drug Discovery & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the development of novel therapeutics for conditions like diabetes insipidus, septic shock, and bleeding disorders.
• Peptide Chemistry Studies: Employed in academic and industrial labs to investigate peptide stability, modification techniques, and synthetic pathways.
• Diagnostic Agent Development: Potential use in the formulation of diagnostic kits or imaging agents targeting vasopressin pathways.

Basic Information

Product Name	Vasopressin, (5-(N(4),N(4)-Dimethyl-Asn)-8-Lys)-
CAS No.	72449-67-3
Molecular Formula	C48H70N14O13S2
Molecular Weight	1115.3 g/mol
Synonyms	[8-Lysine]vasopressin; [Lys8]Vasopressin; 5-(N(4),N(4)-Dimethylasparagine)-8-lysine vasopressin; Desmopressin analogue; dDAVP analogue; 1-(3-Mercaptopropanoic acid)-2-(O-methyl-L-tyrosine)-4-L-valine-8-D-arginine-vasopressin (related); V2 receptor agonist peptide; Cyclo(1-6)-Cys-Tyr-Phe-Gln-Asn(NMe2)-Cys-Pro-Lys-Gly-NH2
EINECS	Contact for details

Quality Control

Our Vasopressin, (5-(N(4),N(4)-Dimethyl-Asn)-8-Lys)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and potency, aligning with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological limits are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0% (Total Peptide Content)
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.