Description

Lypressin is a synthetic analogue of the antidiuretic hormone vasopressin, specifically designed for intranasal administration in the management of central diabetes insipidus. It delivers reliable, short-duration antidiuretic activity with improved stability over natural vasopressin—making it essential for consistent clinical and research outcomes. Pharmaceutical manufacturers, contract development and manufacturing organizations (CDMOs), and clinical research laboratories rely on high-purity lypressin for formulation development, stability studies, and diagnostic reagent production. Lypressin CAS NO 50-57-7 is supplied under strict quality governance to meet global regulatory expectations.

Application

• Intranasal formulation development for central diabetes insipidus treatment
• Active pharmaceutical ingredient (API) in registered prescription nasal sprays
• Reference standard for HPLC and LC-MS method validation in bioanalytical labs
• Stability-indicating assay component in forced degradation studies
• Controlled-release excipient compatibility testing in nasal delivery systems
• Pharmacodynamic research on V2 receptor selectivity and duration-of-action profiling
• Calibration standard for immunoassays measuring antidiuretic hormone analogues
• GMP-compliant raw material for sterile nasal solution manufacturing

Basic Information

Product Name	Lypressin
CAS No.	50-57-7
Molecular Formula	C46H68N14O12S2
Molecular Weight	1069.25 g/mol
Synonyms	8-Lysine vasopressin; Lys-vasopressin; [Lys⁸]vasopressin; 8-Lys-vasopressin; Lypressin acetate; Vasopressin, 8-L-lysyl-; Lypressin (USP); Desmopressin-related analogue; 8-Lysine-oxytocin (historical misnomer)
EINECS	200-036-6

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches conform to USP Monograph requirements for Lypressin, including identity (IR, HPLC, amino acid analysis), assay (≥98.0% by HPLC), related substances (total impurities ≤2.0%), residual solvents (ICH Q3C compliant), and microbiological limits (absence of specified microorganisms). Testing is performed in ISO 17025-accredited laboratories, and documentation supports FDA, EMA, PMDA, and Health Canada submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C (refrigerated) under dry, inert atmosphere to prevent moisture absorption and oxidative degradation. Keep away from sources of heat and humidity. Handle in a controlled environment with low ambient humidity (<30% RH) during weighing and dispensing.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay	98.0–102.0% (by HPLC)
Related Substances	Total impurities ≤2.0%
Residual Solvents	Meets ICH Q3C Class 3 limits
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm
Microbial Limits	Total aerobic count ≤100 CFU/g; absence of E. coli, S. aureus, P. aeruginosa, S. typhimurium

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.