Description

Vasopressin, n-Gly-8-Lys- is a synthetic analogue of the endogenous neurohypophysial hormone vasopressin, specifically modified at the 8-position with a lysine residue and featuring a glycyl group at the N-terminus. This structural modification is critical for enhancing its stability and receptor-binding profile, making it a valuable tool for advanced biochemical and pharmacological research. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in neuroendocrinology, cardiovascular studies, and the development of peptide-based therapeutics.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies investigating vasopressin receptor (V1a, V1b, V2) signaling pathways, antidiuretic mechanisms, and blood pressure regulation.
• Biochemical Assay Development: Serves as a critical component in the development and validation of high-throughput screening (HTS) assays, ELISA kits, and radioimmunoassays (RIA) for vasopressin and related peptides.
• Neuroscience Studies: Applied in experimental models to study the role of vasopressin in social behavior, stress response, memory consolidation, and circadian rhythms.
• Drug Discovery & Preclinical Testing: Acts as a lead compound or intermediate for the synthesis and evaluation of novel peptide therapeutics targeting conditions like diabetes insipidus, septic shock, and bleeding disorders.
• Academic & Clinical Research: Employed in university and hospital laboratories for fundamental research into endocrine disorders, renal function, and cardiovascular diseases.
• Quality Control & Standardization: Used as a certified reference material (CRM) or system suitability standard in analytical laboratories to ensure the accuracy and precision of vasopressin quantification in various matrices.

Basic Information

Product Name	Vasopressin, n-Gly-8-Lys-
CAS No.	4235-50-1
Molecular Formula	C49H70N14O13S2
Molecular Weight	1111.3 g/mol
Synonyms	Glycyl-8-Lysine-vasopressin; [8-Lys]Vasopressin; LVP (Lysine Vasopressin) analogue; Gly-Lys-Vasopressin; Argipressin, 8-Lys-; H-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (cyclic 1-6 disulfide); Vasopressin Gly-Lys-8; 8-L-Vasopressin
EINECS	Contact for details

Quality Control

Our Vasopressin, n-Gly-8-Lys- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and potency, aligning with standards expected for research-grade peptides. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for HPLC purity, amino acid analysis, mass spectrometry (MS), and peptide content.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular ion peak matches theoretical mass
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.