Description

Vasopressin, Deamino(4-Thr-8-Arg)- CAS NO 58928-37-3 is a synthetic analogue of the neurohypophysial hormone vasopressin, specifically engineered with a deamination at position 1 and amino acid substitutions at positions 4 and 8. This modification is critical for enhancing its receptor selectivity and metabolic stability, making it a valuable research tool and a key intermediate in advanced pharmaceutical development. It is primarily utilized by biopharmaceutical R&D teams and manufacturers focused on developing novel therapeutics for endocrine disorders, cardiovascular research, and renal function studies.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel vasopressin receptor agonists and antagonists.
• Endocrinology Studies: Used in preclinical research to investigate the V1 and V2 receptor pathways, water balance, blood pressure regulation, and central nervous system functions.
• Biochemical Assay Development: Serves as a critical component in the development and validation of high-throughput screening (HTS) assays and diagnostic kits targeting vasopressin pathways.
• Peptide Chemistry & Synthesis: An important building block for medicinal chemists synthesizing more complex peptide conjugates or exploring structure-activity relationships (SAR).
• Academic Research: Employed in university and institutional labs for fundamental studies in neuroendocrinology, physiology, and peptide hormone action.
• Quality Control Laboratories: Used as a certified reference material (CRM) for the identification and quantification of vasopressin analogues in pharmaceutical quality control (QC) testing.

Basic Information

Item	Detail
Product Name	Vasopressin, Deamino(4-Thr-8-Arg)- CAS NO 58928-37-3
CAS No.	58928-37-3
Molecular Formula	C46H65N13O12S2
Molecular Weight	1048.2 g/mol
Synonyms	Desmopressin Impurity C; [1-Deamino, 4-Threonine, 8-D-Arginine] Vasopressin; dDAVP Impurity C; Deamino-4-Thr-8-Arg-Vasopressin; 1-Desamino-8-D-arginine vasopressin analogue; 4-Thr-8-Arg-Vasopressin, 1-Deamino-; (4-Thr,8-Arg)-Vasopressin, 1-Deamino-; Vasopressin, 1-deamino-4-threonine-8-arginine-
EINECS	Contact for details

Quality Control

Our Vasopressin, Deamino(4-Thr-8-Arg)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or CoA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.