Description

3-Carbomethoxy Rifamycin S is a key semi-synthetic derivative of the rifamycin antibiotic family, serving as a crucial intermediate in the synthesis of advanced antimicrobial agents. Its primary value lies in enabling the development of more potent and targeted rifamycin-based pharmaceuticals. This compound is essential for research institutions and pharmaceutical manufacturers focused on antibiotic development, particularly for treating tuberculosis and other serious bacterial infections.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of next-generation rifamycin antibiotics, such as rifampicin and rifabutin.
• Antibiotic Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop novel antimicrobial compounds with improved efficacy and reduced resistance.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the controlled production processes of final drug substances for anti-tuberculosis and anti-MRSA treatments.
• Biochemical Research: Utilized as a tool compound to study bacterial RNA polymerase inhibition mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.

Basic Information

Product Name	3-Carbomethoxy Rifamycin S
CAS No.	72393-97-6
Molecular Formula	C38H47NO13
Molecular Weight	725.78 g/mol
Synonyms	Rifamycin S, 3-Carbomethoxy; 3-Carbomethoxyrifamycin S; 3-Methoxycarbonylrifamycin S; 3-(Methoxycarbonyl)rifamycin S; Rifamycin S 3-carbomethoxy derivative; 23-(Methoxycarbonyl)rifamycin S; (12Z,14E,24E)-(2S,12S,13S,14R,15S,16S,17R,18R,19S,20R,21S,22R,23S)-5,6,9,17,19-Pentahydroxy-23-methoxy-1,11-dioxo-4,10-dioxahexacyclo[11.11.2.12,15.02,10.018,22.020,23]tetracosa-12,14,24-triene-13-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 3-Carbomethoxy Rifamycin S is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. Keep the container in a dry, cool, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Reddish-brown to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.