Description

Naloxazine CAS NO 71786-91-9 is a specialized pharmaceutical intermediate and research chemical belonging to the class of opioid antagonists. This compound is of significant interest in advanced pharmacological research and development, particularly for studying opioid receptor mechanisms. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of novel opioid receptor antagonists and related therapeutic compounds.
• Biochemical Research: Used as a reference standard and active agent in studies investigating opioid receptor binding, selectivity, and signal transduction pathways.
• Neuropharmacology: Employed in preclinical research to explore the modulation of pain perception and the development of potential treatments for substance use disorders.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for method development and quality control in analytical laboratories.
• Fine Chemical Synthesis: A critical precursor for medicinal chemists developing new chemical entities (NCEs) with targeted activity at opioid receptors.

Basic Information

Product Name	Naloxazine
CAS No.	71786-91-9
Molecular Formula	C22H27NO4
Molecular Weight	369.46 g/mol
Synonyms	17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one; Naloxazine; EN-1639A; 6-Oxo-naloxone; 6-Keto-naloxone; 6-Oxonaloxone; 6-Oxonaltrexone (related structural analog)
EINECS	Contact for details

Quality Control

Our Naloxazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.