Description

Octanoylpolymyxin B is a semi-synthetic derivative of the polymyxin B antibiotic, modified with an octanoyl group to potentially alter its physicochemical and biological properties. This modification is significant for researchers and formulators seeking to fine-tune the activity, solubility, or stability profile of this important class of antimicrobial agents. It is primarily utilized in advanced pharmaceutical research, antimicrobial susceptibility testing, and the development of novel therapeutic formulations targeting multidrug-resistant Gram-negative bacteria.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the synthesis and study of novel polymyxin derivatives with improved therapeutic indices.
• Antimicrobial Susceptibility Testing (AST): Used in microbiological laboratories to study bacterial resistance mechanisms and evaluate the efficacy of modified antibiotic structures.
• Biochemical Studies: Investigation of structure-activity relationships (SAR) to understand how acyl chain modifications affect membrane disruption and antibacterial potency.
• Formulation Development: Exploration in topical, ophthalmic, or inhalable drug delivery systems where modified solubility or reduced toxicity is desired.
• Reference Standard: Serves as a characterized compound for analytical method development, quality control, and regulatory submissions in antibiotic manufacturing.

Basic Information

Product Name	Octanoylpolymyxin B
CAS No.	71140-58-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-Octanoylpolymyxin B; Polymyxin B Octanoyl Derivative; Octanoyl-polymyxin B; Fatty Acylated Polymyxin B
EINECS	Contact for details

Quality Control

Our Octanoylpolymyxin B is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), identification (by IR/MS), and other critical parameters is provided with every shipment to support your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.