Description

(5S)-26'-Deoxo-1',2',5,28-Tetrahydro-26'-Thioxo-18-De[2-[(1-Carbamoylethenyl)Amino]-1-Methylene-2-Oxoethyl]Siomycin A is a structurally complex derivative of the siomycin family of thiopeptide antibiotics. This compound is of significant interest in advanced pharmaceutical research and development due to its potential as a scaffold for novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of new antibiotics and the study of bacterial protein synthesis inhibition.

Application

• Pharmaceutical R&D: Serves as a key intermediate or reference standard in the development of next-generation antibacterial agents targeting drug-resistant pathogens.
• Biochemical Research: Used as a potent inhibitor in mechanistic studies of bacterial ribosome function and protein biosynthesis pathways.
• Antibiotic Lead Optimization: Provides a core structure for medicinal chemistry programs aimed at improving pharmacokinetic properties and reducing toxicity of thiopeptide antibiotics.
• Microbiology Studies: Employed in in vitro assays to evaluate antimicrobial activity against Gram-positive bacteria and other susceptible strains.
• Standards and Controls: Functions as a high-purity analytical standard for quality control and method validation in antibiotic manufacturing and research laboratories.

Basic Information

Product Name	(5S)-26'-Deoxo-1',2',5,28-Tetrahydro-26'-Thioxo-18-De[2-[(1-Carbamoylethenyl)Amino]-1-Methylene-2-Oxoethyl]Siomycin A
CAS No.	70591-38-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	18-De(2-[(1-Carbamoylethenyl)amino]-1-methylene-2-oxoethyl)siomycin A; Siomycin A derivative; Thiopeptide antibiotic derivative; (5S)-modified Siomycin A; Antibiotic Siomycin A analog; 26'-Thioxo-siomycin derivative; Research antibiotic intermediate; CAS 70591-38-7
EINECS	Contact for details

Quality Control

Our (5S)-26'-Deoxo-1',2',5,28-Tetrahydro-26'-Thioxo-18-De[2-[(1-Carbamoylethenyl)Amino]-1-Methylene-2-Oxoethyl]Siomycin A is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and chromatographic data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Assay	≥ 90.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.