Description

Poly(2'-Chloro-2'-Deoxyinosinic Acid).Polycytidylic Acid is a synthetic, double-stranded polynucleotide complex, widely recognized for its role as a potent interferon inducer and immunomodulator. This compound is critical for advanced research in virology, oncology, and immunology, where it is used to stimulate the immune system and study antiviral and antitumor mechanisms. It is an essential reagent for pharmaceutical R&D, academic research institutions, and biotechnology companies developing novel therapeutic approaches.

Application

• Immunological Research: As a potent inducer of interferon production for studying innate immune responses and antiviral states.
• Oncology Studies: Used in preclinical research to investigate antitumor activities and immune-mediated cancer therapies.
• Virology Research: Employed as a model compound to study viral replication inhibition and host defense mechanisms.
• Vaccine Adjuvant Development: Investigated for its potential to enhance immune responses in next-generation vaccine formulations.
• Biochemical Reagent: Serves as a high-purity standard and critical reagent in molecular biology and biochemistry laboratories.
• Pharmaceutical Intermediates: Used in the research and development of immunomodulatory and antiviral drug candidates.

Basic Information

Product Name	Poly(2'-Chloro-2'-Deoxyinosinic Acid).Polycytidylic Acid
CAS No.	70368-44-4
Molecular Formula	(C10H12ClN4O6P)n.(C9H14N3O7P)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly(I:C12U); Poly(ICLC); Poly I:C (Chlorinated Analog); Polyinosinic-Polycytidylic Acid, Chlorinated; 2'-Chloro-2'-deoxyinosinic acid–cytidylic acid copolymer; Poly(IC) analog; Ampligen precursor; Hiltonol® (related formulation); Poly I:C12U
EINECS	Contact for details

Quality Control

Our Poly(2'-Chloro-2'-Deoxyinosinic Acid).Polycytidylic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as polynucleotide length, duplex integrity, endotoxin levels, and biological activity. We adhere to cGMP guidelines where applicable to support our clients' preclinical and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term stability, store desiccated. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white fibrous solid or lyophilized powder
Identification (UV-Vis)	Characteristic absorption spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95% (as polynucleotide complex)
Duplex Integrity	≥ 90% double-stranded
Endotoxin	< 10 EU/mg
Biological Activity (Cell-based)	Induces interferon-alpha production in standardized assay
Solubility	Soluble in sterile water or PBS (pH 7.2-7.4)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.