Description

Methicillin Sodium (500 Mg) (As) is a semi-synthetic penicillinase-resistant β-lactam antibiotic. This compound is critical for research and development in antimicrobial resistance and serves as a key reference standard in pharmaceutical quality control. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and academic research institutions engaged in antibiotic development and microbiological studies.

Application

• Pharmaceutical reference standard for quality assurance and method validation.
• Active Pharmaceutical Ingredient (API) in research formulations for penicillinase-resistant antibiotics.
• Microbiological research, particularly in studies of Staphylococcus aureus and β-lactamase resistance mechanisms.
• Use in clinical laboratory settings for susceptibility testing and assay development.
• Preparation of calibrated solutions for HPLC and other chromatographic analytical methods.
• Biochemical research involving the study of bacterial cell wall synthesis inhibition.

Basic Information

Item	Detail
Product Name	Methicillin Sodium (500 Mg) (As)
CAS No.	7246-14-2
Molecular Formula	C17H19N2NaO6S
Molecular Weight	402.40 g/mol
Synonyms	Meticillin Sodium; Sodium Methicillin; Dimethoxyphenyl penicillin sodium salt; (2S,5R,6R)-6-[(2,6-Dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt; Staphcillin; Celbenin; BRL-1241; Methicillin Sodium Salt
EINECS	230-646-3

Quality Control

Our Methicillin Sodium is produced and tested under strict quality management systems. Each batch undergoes comprehensive analysis to ensure identity, purity, and potency, meeting the requirements for use as a reference material. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, related substances, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	NLT 95.0% and NMT 102.0% (on anhydrous basis)
pH (10% solution)	5.5 - 7.5
Water Content (KF)	NMT 5.0%
Related Substances (HPLC)	Total impurities NMT 2.0%
Specific Optical Rotation	+267° to +280° (c=1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.