Description

Colistin B is a key polypeptide antibiotic component, specifically the polymyxin E1 variant, essential for its potent bactericidal activity against Gram-negative bacteria. Its primary commercial value lies in its critical role as an active pharmaceutical ingredient (API) in human and veterinary medicine, particularly for treating multidrug-resistant infections. This high-purity compound is indispensable for pharmaceutical manufacturers, research institutions, and veterinary drug formulators requiring a reliable and quality-assured supply of this last-resort antibiotic.

Application

• Pharmaceutical API: Core active ingredient in injectable and topical formulations for treating severe Gram-negative bacterial infections in humans.
• Veterinary Medicine: Used in the manufacture of medications for treating bacterial infections in livestock and companion animals.
• Clinical Research: Serves as a reference standard and investigational compound in antimicrobial resistance (AMR) studies and new drug development.
• Microbiology & Diagnostics: Employed in culture media and sensitivity testing to study bacterial susceptibility patterns.
• Veterinary Feed Additive: Historically used in some regions for growth promotion and disease prevention in animal husbandry (subject to regional regulations).

Basic Information

Product Name	Colistin B
CAS No.	7239-48-7
Molecular Formula	C52H98N16O13
Molecular Weight	1155.44 g/mol
Synonyms	Polymyxin E1; Colistin A; Colistin sulfate component B; Antibiotic 136; Colimycin; Coly-Mycin; Polymyxin E; [D-Leu1]-Colistin A; E1 Polymyxin
EINECS	Contact for details

Quality Control

Our Colistin B is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and potency, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) detailing all test results are provided with every shipment to guarantee traceability and compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Specific Rotation	Contact for details
Bacterial Endotoxins	< 0.5 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.