Description

3-Des(Allylthio)Methyl-3-Bromomethyl Althiazide is a high-purity, advanced pharmaceutical intermediate used in the synthesis of novel therapeutic agents. This compound is valued for its specific bromomethyl functionality, which serves as a key reactive site for constructing complex molecular architectures in medicinal chemistry. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of next-generation diuretic or antihypertensive drug candidates and other specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block in the research and development of new thiazide and thiazide-like diuretic compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to modify and optimize drug candidates targeting ion channels and transporters.
• Process Chemistry: Serves as a key precursor in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological pathways related to electrolyte balance and blood pressure regulation.

Basic Information

Product Name	3-Des(Allylthio)Methyl-3-Bromomethyl Althiazide
CAS No.	7181-60-4
Molecular Formula	C13H15BrN2O4S2
Molecular Weight	407.30 g/mol
Synonyms	3-Bromomethyl-3-des(allylthio)methyl althiazide; 3-Des(Allylthio)methyl-3-(bromomethyl)althiazide; Althiazide Impurity; Althiazide Related Compound; 6-Chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide (bromomethyl derivative); 7181-60-4
EINECS	Contact for details

Quality Control

Our 3-Des(Allylthio)Methyl-3-Bromomethyl Althiazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specified parameters. We support development and commercial projects requiring material that meets ICH guidelines for impurities and stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.