Description

Nafcillin Sodium Salt Monohydrate CAS NO 7177-50-6 is a semi-synthetic, β-lactamase-resistant penicillin antibiotic in its sodium salt form. This compound is critical for research and development in combating penicillin-resistant bacterial strains. It is primarily utilized by pharmaceutical manufacturers, research institutions, and quality control laboratories for the development of antibacterial agents and microbiological studies.

Application

• Pharmaceutical Active Ingredient (API): Used in the formulation of injectable antibiotic preparations for the treatment of infections caused by susceptible Gram-positive bacteria.
• Microbiological Research: Serves as a key reference standard and selective agent in studies of bacterial resistance mechanisms, particularly against β-lactamase-producing organisms like Staphylococcus aureus.
• Quality Control & Analytical Testing: Employed as a high-purity analytical standard in HPLC, UV, and other chromatographic methods for assay validation and impurity profiling in pharmaceutical quality assurance.
• Clinical Laboratory Reagent: Used in diagnostic kits and media for antibiotic susceptibility testing (AST) to determine bacterial resistance profiles.
• Biochemical Studies: Applied in research investigating the synthesis and inhibition of bacterial cell walls.
• Veterinary Medicine: Potential use in developing treatments for bacterial infections in animals.

Basic Information

Product Name	Nafcillin Sodium Salt Monohydrate
CAS No.	7177-50-6
Molecular Formula	C21H21N2NaO5S · H2O
Molecular Weight	454.46 g/mol (Monohydrate)
Synonyms	Nafcillin Sodium Monohydrate; Sodium Nafcillin Monohydrate; 6-(2-ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt monohydrate; Wy-3277; Unipen; Nafcil; Naftopen; Ethoxynaphthamidopenicillin Sodium Salt Monohydrate
EINECS	Contact for details

Quality Control

Our Nafcillin Sodium Salt Monohydrate is manufactured and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency, meeting high standards suitable for pharmaceutical research. A Certificate of Analysis (COA) detailing results for assay, related substances, water content, and microbiological tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC, anhydrous basis)	98.0% - 102.0%
Water Content (KF)	3.0% - 5.0%
pH (1% solution)	5.0 - 7.5
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Bacterial Endotoxins	<0.17 EU/mg (if applicable)
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.