Description

Chlorothiazide Sodium is the sodium salt form of the thiazide diuretic, chlorothiazide, offering enhanced solubility for formulation. This compound is a critical active pharmaceutical ingredient (API) and a key intermediate in the synthesis of advanced pharmaceutical products. It is primarily required by manufacturers in the pharmaceutical industry for the production of diuretic and antihypertensive medications, as well as by research institutions for pharmacological studies.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of prescription diuretic medications.
• Antihypertensive Formulations: A key component in drugs designed to manage high blood pressure, often in combination with other agents.
• Research & Development: Used in preclinical and clinical research to study renal function, electrolyte balance, and cardiovascular pharmacology.
• Reference Standard: Serves as a high-purity analytical standard for quality control testing in pharmaceutical laboratories.
• Chemical Synthesis: Acts as a crucial synthetic intermediate for producing more complex thiazide derivatives and related compounds.

Basic Information

Product Name	Chlorothiazide Sodium
CAS No.	7085-44-1
Molecular Formula	C7H5ClN3NaO4S2
Molecular Weight	317.71 g/mol
Synonyms	6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide sodium salt; Sodium Chlorothiazide; Chlorothiazide Sodium Salt; 6-Chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide sodium salt; Azide Sodium; Diuril Sodium; Saluric Sodium; HydroDIURIL Intermediate
EINECS	230-402-5

Quality Control

Our Chlorothiazide Sodium is manufactured under strict quality management systems. It is typically tested to meet high-purity standards suitable for pharmaceutical applications, with specifications aligning with common pharmacopeial requirements. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with each batch to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.