Description

3-Nitro-4-(Trifluoromethoxyl)Benzoic Acid is a high-value, multi-functional aromatic building block characterized by its unique combination of electron-withdrawing nitro and trifluoromethoxy substituents. This compound is essential for advanced organic synthesis, offering a versatile scaffold for constructing complex molecules with tailored electronic and steric properties. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, crop protection, and material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a substituted benzoic acid core with enhanced lipophilicity and metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers, liquid crystals, and organic electronic materials due to its ability to modify electronic properties.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	3-Nitro-4-(Trifluoromethoxyl)Benzoic Acid
CAS No.	784-77-0
Molecular Formula	C8H4F3NO5
Molecular Weight	251.12 g/mol
Synonyms	4-(Trifluoromethoxy)-3-nitrobenzoic acid; Benzoic acid, 3-nitro-4-(trifluoromethoxy)-; 3-Nitro-4-trifluoromethoxybenzoic acid; 784-77-0; 4-Trifluoromethoxy-3-nitrobenzoic acid; 3-Nitro-4-(trifluoromethoxy)benzoic acid; 3-Nitro-4-(trifluoromethoxy)benzoic acid (ACI)
EINECS	Contact for details

Quality Control

Every batch of 3-Nitro-4-(Trifluoromethoxyl)Benzoic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with a detailed Certificate of Analysis (COA) for each lot, which includes data from HPLC, NMR, and IR spectroscopy. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. The compound is stable under recommended conditions but should be handled with standard precautions for laboratory chemicals.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.