Description

(S)-(-)-2-(Trifluoroacetamido)Succinic Anhydride is a high-value chiral building block and key intermediate in organic synthesis. Its core value lies in its ability to introduce a protected amino acid moiety with a trifluoroacetyl group, which is crucial for the synthesis of complex, optically active molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs), peptide mimetics, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel APIs, especially in oncology and neurology drug discovery.
• Peptide Chemistry: Used in the preparation of modified peptides and peptidomimetics, where the trifluoroacetamido group serves as a protective handle.
• Agrochemical Synthesis: Employed as a building block for creating chiral herbicides, fungicides, and plant growth regulators.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric reactions to construct complex molecular architectures.
• Material Science Research: Utilized in the development of specialty polymers and advanced organic materials with specific optical properties.
• Bioconjugation: Acts as a reagent for modifying biomolecules, enabling the attachment of probes or functional groups under mild conditions.

Basic Information

Product Name	(S)-(-)-2-(Trifluoroacetamido)Succinic Anhydride
CAS No.	777-33-3
Molecular Formula	C6H4F3NO4
Molecular Weight	211.10 g/mol
Synonyms	(S)-2-(Trifluoroacetamido)succinic anhydride; (S)-N-(Trifluoroacetyl)aspartic anhydride; L-N-(Trifluoroacetyl)aspartic anhydride; (S)-(-)-N-Trifluoroacetyl aspartic anhydride; (S)-Aspartic acid N-trifluoroacetyl anhydride; (2S)-2-[(Trifluoroacetyl)amino]butanedioic anhydride; TFA-Asp anhydride; N-TFA-L-aspartic anhydride
EINECS	Contact for details

Quality Control

Our production of (S)-(-)-2-(Trifluoroacetamido)Succinic Anhydride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure consistency and meet the exacting standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.