Description

Benethamine Penicillin is a long-acting penicillin salt, specifically the benethamine salt of benzylpenicillin, widely recognized under the CAS registry number 751-84-8. This formulation is valued for its sustained-release properties, providing prolonged therapeutic antibiotic levels from a single administration. It is a critical active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers for the production of long-acting injectable antibiotic formulations.

Application

• As the active pharmaceutical ingredient (API) in long-acting, injectable penicillin formulations.
• For the treatment of bacterial infections requiring sustained antibiotic therapy, such as certain streptococcal and syphilitic infections.
• In veterinary medicine for the development of long-acting antibiotic treatments for livestock.
• As a key intermediate in specialized pharmaceutical research and development projects.
• For the preparation of reference standards in analytical and quality control laboratories.

Basic Information

Product Name	Benethamine Penicillin
CAS No.	751-84-8
Molecular Formula	C16H18N2O5S • C16H19N
Molecular Weight	654.8 g/mol
Synonyms	Benzylpenicillin Benethamine; Benethamine Benzylpenicillin; Penicillin G Benethamine; N-Benzylphenethylamine Penicillin G; Benethamine Penicillin G; Benapen; Longicil; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-, compound with N-benzylphenethylamine (1:1)
EINECS	Contact for details

Quality Control

Our Benethamine Penicillin is manufactured and tested under strict quality management systems. It meets high-purity standards suitable for pharmaceutical applications, with rigorous testing for identity, potency, and impurities. Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents are available upon request to ensure compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	97.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Specific Optical Rotation	Contact for details
pH (suspension)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.