Description

3,5-Bis(Trifluoromethyl)Benzoic Acid is a high-value fluorinated aromatic building block characterized by its two electron-withdrawing trifluoromethyl groups, which impart unique chemical and physical properties. This compound is essential for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where enhanced lipophilicity, metabolic stability, and bioavailability are required. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel compounds and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atoms for improved efficacy and environmental profile.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing sophisticated ligands used in transition metal catalysis and organocatalysis.
• Material Science: Incorporated into the synthesis of monomers for specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research: A versatile building block in medicinal chemistry and organic synthesis for introducing the bis(trifluoromethyl)phenyl moiety.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Benzoic Acid
CAS No.	725-89-3
Molecular Formula	C9H4F6O2
Molecular Weight	258.12 g/mol
Synonyms	3,5-Bis(trifluoromethyl)benzoic acid; Benzoic acid, 3,5-bis(trifluoromethyl)-; α,α,α,α',α',α'-Hexafluoro-3,5-xylene-α,α'-dicarboxylic acid; 3,5-Di(trifluoromethyl)benzoic acid; 3,5-Bis(trifluoromethyl)benzenecarboxylic acid; 3,5-BTFMBA; 725-89-3
EINECS	211-983-4

Quality Control

Our 3,5-Bis(Trifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly closed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	162 - 166 °C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.