Description

5-Methoxy-2-(trifluoromethyl)benzoic acid is a versatile trifluoromethylated aromatic carboxylic acid derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure combines a methoxy electron-donating group with a strongly electron-withdrawing trifluoromethyl group, making it a valuable intermediate for creating compounds with tailored electronic and steric properties. This high-purity intermediate is essential for research and development in the pharmaceutical and agrochemical sectors, where it is used to modulate the bioavailability, metabolic stability, and binding affinity of target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a trifluoromethylated benzoic acid scaffold to enhance lipophilicity and metabolic resistance.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group often contributes to improved biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced electronic materials, where its aromatic core and fluorine atoms help fine-tune dielectric anisotropy and electron transport properties.
• Organic Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs), leveraging the carboxylic acid group for coordination.
• Fluorinated Polymer Modifier: Acts as a monomer or modifier in the synthesis of high-performance polymers, imparting desirable properties like chemical resistance and low surface energy.
• Research & Development: A valuable reagent for medicinal chemistry and process chemistry research in academic and industrial laboratories exploring fluorinated compound libraries.

Basic Information

Product Name	5-Methoxy-2-(Trifluoromethyl)Benzoic Acid
CAS No.	716-31-4
Molecular Formula	C9H7F3O3
Molecular Weight	220.15 g/mol
Synonyms	2-Trifluoromethyl-5-methoxybenzoic acid; 5-Methoxy-α,α,α-trifluoro-o-toluic acid; 5-Methoxy-2-trifluoromethylbenzoic acid; Benzoic acid, 5-methoxy-2-(trifluoromethyl)-; 5-Methoxy-2-(trifluoromethyl)benzoic acid; 2-Carboxy-4-methoxybenzotrifluoride; 4-Methoxy-2-(trifluoromethyl)benzoic acid (alternate numbering)
EINECS	Contact for details

Quality Control

Our 5-Methoxy-2-(trifluoromethyl)benzoic acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.