Description

2,4-Dinitrofluorobenzene CAS NO 70-34-8 is a key fluorinated aromatic compound widely recognized as Sanger's reagent. It is an essential electrophilic derivatization agent, primarily used for the labeling and sequencing of amino acids, peptides, and proteins. This high-purity intermediate is critical for research and development in pharmaceutical synthesis, proteomics, and analytical chemistry laboratories globally.

Application

• Peptide Sequencing & Amino Acid Analysis: Acts as Sanger's reagent for the N-terminal end-group analysis of peptides and proteins via dinitrophenyl (DNP) derivatization.
• Pharmaceutical Intermediate: Serves as a versatile building block in the synthesis of more complex fluorinated and nitro-substituted aromatic compounds for active pharmaceutical ingredients (APIs).
• Proteomics Research: Used for the selective modification of amino groups in biomolecules for mass spectrometry and chromatographic studies.
• Cross-linking Agent: Employed in biochemical research for protein cross-linking and conjugation studies.
• Material Science Intermediate: Utilized in the synthesis of specialty dyes, polymers, and advanced organic materials.
• Analytical Chemistry: Functions as a derivatization reagent in HPLC and other analytical methods to enhance detection of amines and amino acids.

Basic Information

Product Name	2,4-Dinitrofluorobenzene
CAS No.	70-34-8
Molecular Formula	C6H3FN2O4
Molecular Weight	186.10 g/mol
Synonyms	1-Fluoro-2,4-dinitrobenzene; Sanger's Reagent; DNFB; FDNB; 2,4-DNFB; 2,4-Dinitro-1-fluorobenzene; Dinitrofluorobenzene; EINECS 200-734-3
EINECS No.	200-734-3

Quality Control

Our 2,4-Dinitrofluorobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and industrial applications. A detailed Certificate of Analysis (COA) with specifications for identity, purity, and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to yellow-green crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	25 - 28 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.