Description

2-Fluoro-3-(Trifluoromethyl)Cinnamic Acid is a high-value fluorinated organic building block characterized by its cinnamic acid core substituted with fluorine and trifluoromethyl groups. This compound matters for its role as a versatile intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors where the introduction of fluorine atoms is a key strategy to modulate bioactivity and metabolic stability. It is primarily needed by research chemists and process development scientists working on novel active ingredients, including kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, especially in oncology and central nervous system (CNS) disease research.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine moiety enhances efficacy and environmental persistence.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and liquid crystals with unique optical or electronic properties.
• Chemical Biology Probes: Employed in the design of molecular probes and tags for studying biological processes and protein interactions.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, such as Suzuki or Heck reactions, to construct more complex polyfluorinated aromatic systems.

Basic Information

Product Name	2-Fluoro-3-(Trifluoromethyl)Cinnamic Acid
CAS No.	695187-36-1
Molecular Formula	C₁₀H₆F₄O₂
Molecular Weight	234.15 g/mol
Synonyms	(2E)-3-[2-Fluoro-3-(trifluoromethyl)phenyl]prop-2-enoic acid; 2-Fluoro-α,3-bis(trifluoromethyl)cinnamic acid; (E)-2-Fluoro-3-(trifluoromethyl)cinnamic acid; trans-2-Fluoro-3-(trifluoromethyl)cinnamic acid; 3-(2-Fluoro-3-(trifluoromethyl)phenyl)acrylic acid; FTCA; 2-F-3-TFMA
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-(Trifluoromethyl)Cinnamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.